Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings
نویسندگان
چکیده
منابع مشابه
Strategy for the development of new acetylcholinesterase reactivators - antidotes used for treatment of nerve agent poisonings.
The mechanism of intoxication with organophosphorus compounds, including highly toxic nerve agents, is based on the formation of irreversibly inhibited acetylcholinesterase (AChE; EC 3.1.1.7) that could be followed by a generalized cholinergic crisis. Nerve agent poisoning is conventionally treated using a combination of a cholinolytic drug (atropine mostly) to counteract the accumulation of ac...
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ژورنال
عنوان ژورنال: Biomedical Papers
سال: 2005
ISSN: 1213-8118,1804-7521
DOI: 10.5507/bp.2005.074